This is the short version of the Setup Guide: the four articles worth reading before you create anything, whatever else you plan to set up.
They explain what to choose and why. The module sections elsewhere in this knowledge base explain how to do it.
Read Master the Vome fundamentals alongside the first one, since it covers the same structure in more depth.
In seven stages, and you are in the first: Orientation, Recruit, Onboard, Operate, Engage, Manage and Test. Each stage covers the decisions behind one part of building your account, roughly in the order you will meet them.
Each module section has its own short page of setup decisions, pointing back to the Setup Guide articles that matter there. Open the one for whatever you are building: Add Opportunity, Forms, Sequences, Schedule and Hour Tracking, Database, Recruitment workflow, Communications, Reports, Analytics, Sites, or Users and Access.
For account basics such as registering and your organization settings, see the Registration and Settings sections.